Understanding how IL-1 influences brain inflammation and behavior
Official title: Dynamic regulation of neuroinflammation and IL-1b-trap
Funded at Florida Atlantic University · NIH-10726269 · Data updated 2026-11-12
This study is looking at how a special protein called IL-1 affects brain health and behavior, using a unique mouse model to see how it works in both normal and inflamed conditions, which could help us understand mental health issues better.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Florida Atlantic University NIH-funded |
| Lab location | 1 site (Boca Raton, United States) |
| Project start | June 1, 2023 |
| Project end | May 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $419,375 |
| NIH project number | 1R21NS133843-01 |
| Project ID | NIH-10726269 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing mental health disorders or conditions related to neuroinflammation.
✕Less likely to help
Patients with non-neurological conditions or those not affected by mental health disorders may not benefit from this research.
What this research studies
This research investigates the role of IL-1, a key neuroimmune regulator, in brain function and disease. By using a specially designed mouse model that allows researchers to visualize and manipulate IL-1-expressing cells, the study aims to identify how these cells behave under normal and inflammatory conditions. The research will explore the effects of these cells on neurochemistry and behavior, particularly in response to various inflammatory challenges. This could lead to new insights into the mechanisms underlying mental health disorders and other CNS diseases.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating mental health disorders and other central nervous system diseases.
How similar studies have gone: Previous research has shown promising results in understanding neuroinflammation's role in mental health, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Florida Atlantic University
Boca Raton, United States Active
Researchers
- Principal investigator: Quan, Ning — Florida Atlantic University
- Study coordinator: Quan, Ning
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.