Understanding how IgG sialylation affects inflammation
Regulation of IgG Sialylation
['FUNDING_FELLOWSHIP'] · CASE WESTERN RESERVE UNIVERSITY · NIH-10888183
This study is looking at how changes in a specific part of antibodies called IgG can affect the immune system, with the goal of finding new ways to treat inflammation-related diseases that might help patients feel better.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CASE WESTERN RESERVE UNIVERSITY (nih funded) |
| Locations | 1 site (CLEVELAND, UNITED STATES) |
| Trial ID | NIH-10888183 on ClinicalTrials.gov |
What this research studies
This research investigates the regulatory mechanisms that control the sialylation of IgG, a type of antibody involved in immune responses. By exploring how changes in IgG sialylation influence immune activation, the study aims to identify potential therapeutic targets for manipulating inflammation. The approach involves examining the dynamic regulation of IgG sialylation after its release into the bloodstream, which may provide insights into treating various inflammatory diseases. Patients may benefit from findings that could lead to new treatments for conditions linked to dysregulated IgG function.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with inflammatory diseases that may be linked to altered IgG sialylation.
Not a fit: Patients with conditions unrelated to IgG function or inflammation may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to novel therapies that either enhance or suppress IgG-related inflammation, improving treatment options for patients with inflammatory diseases.
How similar studies have performed: Previous research has shown promising results in understanding IgG sialylation, but this specific regulatory approach is relatively novel.
Where this research is happening
CLEVELAND, UNITED STATES
- CASE WESTERN RESERVE UNIVERSITY — CLEVELAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GLENDENNING, LEANDRE — CASE WESTERN RESERVE UNIVERSITY
- Study coordinator: GLENDENNING, LEANDRE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus, Autoimmune Diseases