Understanding how IgG sialylation affects inflammation
Official title: Regulation of IgG Sialylation
Funded at Case Western Reserve University · NIH-10888183 · Data updated 2026-11-12
This study is looking at how changes in a specific part of antibodies called IgG can affect the immune system, with the goal of finding new ways to treat inflammation-related diseases that might help patients feel better.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $42,574 |
| NIH project number | 5F31AI178953-02 |
| Project ID | NIH-10888183 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with inflammatory diseases that may be linked to altered IgG sialylation.
✕Less likely to help
Patients with conditions unrelated to IgG function or inflammation may not receive any benefit from this research.
What this research studies
This research investigates the regulatory mechanisms that control the sialylation of IgG, a type of antibody involved in immune responses. By exploring how changes in IgG sialylation influence immune activation, the study aims to identify potential therapeutic targets for manipulating inflammation. The approach involves examining the dynamic regulation of IgG sialylation after its release into the bloodstream, which may provide insights into treating various inflammatory diseases. Patients may benefit from findings that could lead to new treatments for conditions linked to dysregulated IgG function.
Why it matters
Potential benefit: If successful, this research could lead to novel therapies that either enhance or suppress IgG-related inflammation, improving treatment options for patients with inflammatory diseases.
How similar studies have gone: Previous research has shown promising results in understanding IgG sialylation, but this specific regulatory approach is relatively novel.
Where this research is happening
-
Case Western Reserve University
Cleveland, United States Active
Researchers
- Principal investigator: Glendenning, Leandre — Case Western Reserve University
- Study coordinator: Glendenning, Leandre
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.