Understanding how human voltage gated proton channels work
Official title: Control Mechanisms of Human Voltage Gated Proton Channels, hHv1
Funded at Rush University Medical Center · NIH-11014398 · Data updated 2026-11-12
This study is looking at a special channel in our cells called HV1, which helps with important functions like fighting infections and sending signals in the body, to understand how it works in different tissues and how it might be linked to diseases like cancer and brain injuries, with the hope of finding new ways to help patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rush University Medical Center NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | February 1, 2024 |
| Project end | January 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $391,050 |
| NIH project number | 5R35GM151963-02 |
| Project ID | NIH-11014398 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with autoimmune diseases, chronic lymphocytic leukemia, or those who have suffered from brain injuries.
✕Less likely to help
Patients with conditions unrelated to the functions of HV1 or those not affected by the diseases being studied may not receive any benefit from this research.
What this research studies
This research investigates the voltage gated proton channel (HV1), which is crucial for various bodily functions such as immune response and cell signaling. The study aims to explore how HV1 operates in different human tissues and its implications in diseases like cancer and brain injuries. By examining the structure and function of HV1, researchers hope to uncover mechanisms that could lead to new therapeutic strategies. Patients may benefit from insights gained about HV1's role in health and disease.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for conditions related to abnormal HV1 function, such as cancer and brain injuries.
How similar studies have gone: Other research has shown promising results in understanding voltage gated ion channels, suggesting that this approach could yield significant insights.
Where this research is happening
-
Rush University Medical Center
Chicago, United States Active
Researchers
- Principal investigator: Decoursey, Thomas E — Rush University Medical Center
- Study coordinator: Decoursey, Thomas E
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.