Understanding how human papillomavirus interacts with the immune system
Structural Studies of Human Papillomavirus
This study is looking at how the HPV virus works and how our body's antibodies can help protect us from cancers caused by HPV, with the goal of finding better ways to improve vaccines for everyone at risk.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-10917405 on NIH RePORTER |
What this research studies
This research investigates the structural characteristics of human papillomavirus (HPV) and how it interacts with human cells, particularly focusing on the role of antibodies in providing protection against HPV-related cancers. Using advanced techniques like cryo-electron microscopy, the study aims to map the interactions between HPV capsids and human cells at an atomic level. By identifying the best antibodies that can effectively combat HPV, the research seeks to improve vaccine efficacy and provide better protection against various HPV types that cause cervical, anal, and head and neck cancers.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for HPV-related cancers, including those with a history of cervical, anal, or head and neck cancers.
Not a fit: Patients who are not at risk for HPV-related cancers or those who have already been vaccinated against all HPV types may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective vaccines that provide broader protection against HPV-related cancers.
How similar studies have performed: Previous research has shown promise in understanding HPV interactions and antibody responses, indicating that this approach could lead to significant advancements in vaccine development.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Hafenstein, Susan — University of Minnesota
- Study coordinator: Hafenstein, Susan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.