Understanding how human immune cells develop from stem cells
Lineage tracing origins of human innate lymphoid cells from hematopoietic precursors
This study is looking at how special immune cells called natural killer (NK) cells develop from stem cells in our bodies, which could help us find better treatments for diseases where the immune system isn't working properly.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11032185 on NIH RePORTER |
What this research studies
This research investigates the development of natural killer (NK) cells, which are essential for fighting viral infections, from stem cells in humans. By using a technique called genetic barcoding, researchers will track how these immune cells differentiate from their precursors. The study aims to uncover the complex processes that guide stem cells to become NK cells, including the role of myeloid progenitors. Patients may benefit from insights gained into NK cell development, which could lead to improved treatments for diseases related to immune dysfunction.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who may have conditions related to immune dysfunction or are interested in the biology of immune cells.
Not a fit: Patients with stable immune function and no history of viral infections or immune disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of immune cell development, potentially leading to better therapies for viral infections and immune-related diseases.
How similar studies have performed: Previous research has successfully utilized genetic tracing methods to study cell differentiation, indicating that this approach has potential for yielding valuable insights.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Mace, Emily Margaret — Columbia University Health Sciences
- Study coordinator: Mace, Emily Margaret
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.