Understanding how Hsp70 phosphorylation controls proteostasis
Official title: Understanding the role of Hsp70 phosphorylation in proteostasis
Funded at University of North Carolina Charlotte · NIH-11329973 · Data updated 2026-11-12
This NIH grant explores how a specific modification of the Hsp70 protein helps cells manage protein folding and stress, with a focus on yeast as a model.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of North Carolina Charlotte NIH-funded |
| Lab location | 1 site (Charlotte, United States) |
| Project start | July 10, 2024 |
| Project end | May 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $319,730 |
| NIH project number | 5R01GM149639-03 |
| Project ID | NIH-11329973 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable for this non-human model–focused research; translational relevance may emerge but no patient enrollment is planned.
✕Less likely to help
No direct patient procedures or participation in this grant.
What this research studies
Hsp70 is a key protein that helps other proteins fold correctly. The project will look at how adding a phosphate group to Hsp70 affects its function during heat stress in yeast, including how it influences stress granules and protein aggregates. Researchers will study how this modification might influence cell integrity signaling and the activity of kinases involved in maintaining cell health. The work combines molecular biology, cell biology, and signaling analyses to link a single phosphorylation event to broader proteostasis outcomes.
Why it matters
Potential benefit: If successful, the work could reveal new targets for supporting protein homeostasis in diseases where misfolded proteins accumulate.
How similar studies have gone: Previous studies show phosphorylation can alter chaperone function and stress responses, supporting a plausible impact for this site.
Where this research is happening
-
University of North Carolina Charlotte
Charlotte, United States Active
Researchers
- Principal investigator: Truman, Andrew William — University of North Carolina Charlotte
- Study coordinator: Truman, Andrew William
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.