Understanding how HLA-C affects chronic inflammation in pregnancy
Official title: The role of HLA-C in chronic chorioamnionitis
Funded at Cincinnati Childrens Hosp Med Ctr · NIH-11027190 · Data updated 2026-11-12
This study is looking at how a specific protein called HLA-C affects the immune cells in pregnant women with chronic chorioamnionitis, a condition that causes inflammation in the placenta, to help find better ways to treat it and improve pregnancy health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | January 1, 2025 |
| Project end | November 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $630,107 |
| NIH project number | 1R01HD116852-01 |
| Project ID | NIH-11027190 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are pregnant individuals experiencing chronic chorioamnionitis or related complications.
✕Less likely to help
Patients who are not pregnant or those without any signs of chronic chorioamnionitis may not benefit from this research.
What this research studies
This research investigates the role of Human Leukocyte Antigen-C (HLA-C) in chronic chorioamnionitis (CCA), a condition characterized by inflammation of the placental membranes. The study aims to clarify how HLA-C influences the activity of maternal CD8 T cells, which can contribute to tissue damage during pregnancy. By examining the interactions between HLA-C and these immune cells, the research seeks to uncover the underlying mechanisms that lead to excessive cell death in the placenta. This could ultimately inform new treatment strategies for managing CCA and improving pregnancy outcomes.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for chronic chorioamnionitis, potentially reducing risks associated with pregnancy complications.
How similar studies have gone: Previous research has shown promising results in understanding immune responses in pregnancy, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Cincinnati Childrens Hosp Med Ctr
Cincinnati, United States Active
Researchers
- Principal investigator: Tilburgs, Tamara — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Tilburgs, Tamara
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.