Understanding how HIV and methamphetamine affect brain inflammation
Modeling HIV and methamphetamine-induced neuroinflammation in cerebral organoids
This study is looking at how HIV and methamphetamine affect brain inflammation and thinking skills by using special 3D brain models, which could help find better treatments for cognitive problems in people living with HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-10890075 on NIH RePORTER |
What this research studies
This research investigates the effects of HIV and methamphetamine on brain inflammation using advanced 3D brain models called cerebral organoids. By studying microglia, the brain's immune cells, derived from stem cells, the research aims to uncover the mechanisms that lead to neuroinflammation and cognitive decline in individuals with HIV. The approach combines cellular biology and neuroscience to better understand how these factors contribute to neurocognitive disorders. Patients may benefit from insights that could lead to improved treatments for cognitive issues associated with HIV.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who may be experiencing cognitive challenges or are at risk for neurocognitive disorders.
Not a fit: Patients who are not infected with HIV or do not have cognitive impairments related to HIV may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies to mitigate cognitive decline in HIV-infected individuals.
How similar studies have performed: Previous research has shown that studying neuroinflammation in HIV-infected individuals can yield valuable insights, suggesting that this approach may be promising.
Where this research is happening
Cincinnati, United States
- Cincinnati Childrens Hosp Med Ctr — Cincinnati, United States (Active)
Researchers
- Principal investigator: Spearman, Paul W. — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Spearman, Paul W.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.