Understanding how HIV affects heart disease risk in older adults
Investigating Cellular Immunometabolic Mechanisms Underlying HIV-Related Cardiovascular Disease Risk
['FUNDING_R01'] · WEILL MEDICAL COLL OF CORNELL UNIV · NIH-10902070
This study is looking at how living with HIV might affect heart health in older adults by exploring the ways the immune system and inflammation could increase the risk of heart disease, and it’s for older people with HIV who want to understand more about their health.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WEILL MEDICAL COLL OF CORNELL UNIV (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10902070 on ClinicalTrials.gov |
What this research studies
This research investigates the complex relationship between HIV and cardiovascular disease (CVD) risk in older adults living with HIV. It focuses on identifying the biological mechanisms that contribute to increased CVD risk, particularly through the lens of immunometabolism and inflammation. By studying a cohort of older individuals with HIV, the research aims to uncover specific immune cell types and metabolic changes that are linked to heart disease. Participants will undergo various assessments to help clarify how these factors interact and contribute to cardiovascular health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 50 and older who are living with HIV and are on effective antiretroviral therapy.
Not a fit: Patients who are younger than 50 or not living with HIV may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to targeted therapies that reduce cardiovascular disease risk in older adults living with HIV.
How similar studies have performed: Previous research has indicated that understanding immunometabolic dysfunction can provide insights into age-related comorbidities in HIV, suggesting potential for success in this area.
Where this research is happening
NEW YORK, UNITED STATES
- WEILL MEDICAL COLL OF CORNELL UNIV — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CORLEY, MICHAEL JAY — WEILL MEDICAL COLL OF CORNELL UNIV
- Study coordinator: CORLEY, MICHAEL JAY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus, Atherosclerotic Cardiovascular Disease