Understanding how HIV affects brain cells and leads to neurological disorders
Investigating the molecular mechanisms of HIV/AIDS associated neurological disorders using microglia and cerebral organoids derived from induced pluripotent stem cells
This study is looking at how HIV affects brain cells called microglia and how this might lead to memory and thinking problems in people with HIV, using special lab-grown brain models to find ways to help improve treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10672955 on NIH RePORTER |
What this research studies
This research investigates the effects of HIV on microglia, the immune cells in the brain, and how this interaction contributes to neurological disorders associated with HIV. Using advanced techniques, the researchers will create brain-like structures from stem cells to study the cellular changes caused by HIV infection. The goal is to uncover the molecular mechanisms that lead to neuronal injury and cognitive impairments in patients with HIV-associated neurocognitive disorders. By understanding these processes, the research aims to identify potential therapeutic targets for treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals living with HIV who are experiencing cognitive or neurological symptoms.
Not a fit: Patients who do not have HIV or those without neurological symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve cognitive function and quality of life for individuals living with HIV-associated neurological disorders.
How similar studies have performed: Previous research has shown promising results in understanding the interactions between HIV and brain cells, but this specific approach using induced pluripotent stem cells is relatively novel.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Rana, Tariq M — University of California, San Diego
- Study coordinator: Rana, Tariq M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.