Understanding how HIV-1 moves within host cells
Official title: Determining the Molecular Basis for HIV-1 Retrograde Trafficking
Funded at University of Michigan at Ann Arbor · NIH-11098731 · Data updated 2026-11-12
This study is looking at how the HIV-1 virus moves into the center of our cells after it infects them, focusing on a helper protein called dynein, and it hopes to find new ways to stop the virus from spreading.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | June 1, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $773,808 |
| NIH project number | 5R01AI183968-02 |
| Project ID | NIH-11098731 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV-1 who are seeking new treatment options.
✕Less likely to help
Patients who are not infected with HIV-1 or those with advanced AIDS may not benefit from this research.
What this research studies
This research investigates the mechanisms by which the HIV-1 virus transports itself to the nucleus of host cells after infection. It focuses on the role of dynein, a motor protein, and its interaction with HIV-1, exploring how the virus can exploit this transport system to facilitate its replication. By using advanced microscopy techniques, the researchers aim to uncover the molecular details of this process, which could lead to new strategies for disrupting HIV-1's ability to infect cells.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that prevent HIV-1 from effectively replicating within host cells.
How similar studies have gone: Previous research has shown promising results in understanding viral transport mechanisms, indicating that this approach has potential for success.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Cianfrocco, Michael — University of Michigan at Ann Arbor
- Study coordinator: Cianfrocco, Michael
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.