Understanding how histone proteins influence gene regulation in cells
Molecular mechanisms of histone signaling in a chromatin relevant context
This study is looking at how special proteins called histones help control our genes and how changes to these proteins can affect how our cells behave, which could help us understand how our bodies respond to different situations.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-10873737 on NIH RePORTER |
What this research studies
This research investigates the role of histone proteins in the regulation of genes within the human genome, focusing on how these proteins undergo modifications that affect gene expression. By utilizing advanced techniques like NMR spectroscopy, the study aims to uncover the molecular mechanisms that allow specific reader domains to interpret these histone modifications in a chromatin context. This could lead to a better understanding of how cells respond to various developmental and environmental signals, ultimately influencing cell fate and function.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to gene regulation, such as certain cancers or autoimmune diseases.
Not a fit: Patients with conditions unrelated to gene regulation or chromatin dynamics may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into gene regulation that may improve treatments for various diseases, including cancers and autoimmune disorders.
How similar studies have performed: While the specific approach of using NMR spectroscopy in this context may be novel, research in epigenomics has shown promising results in understanding gene regulation.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Musselman, Catherine Anne — University of Colorado Denver
- Study coordinator: Musselman, Catherine Anne
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.