Understanding how hepatitis B virus spreads in the liver
Official title: NIH: Spatial Models of Intrahepatic Hepatitis Virus Propagation in Humans
Funded at Triad National Security, LLC · NIH-11012379 · Data updated 2026-11-12
This study is looking at how the hepatitis B virus affects the liver and aims to find better ways to treat it, especially for people who also have HIV or hepatitis C, so that patients can have more effective treatment options and possibly even a cure.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Triad National Security, LLC NIH-funded |
| Lab location | 1 site (Los Alamos, UNITED STATES) |
| Project start | February 7, 2022 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $867,166 |
| NIH project number | 5R01AI116868-09 |
| Project ID | NIH-11012379 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with chronic hepatitis B, particularly those with co-infections such as HIV or hepatitis C.
✕Less likely to help
Patients who do not have chronic hepatitis B or related liver diseases may not receive any benefit from this research.
What this research studies
This research investigates the complex lifecycle of the hepatitis B virus (HBV) and its impact on liver disease. By analyzing unique liver tissue samples and utilizing advanced techniques for single-cell analysis, the study aims to develop new models that can better inform clinical treatments for chronic hepatitis B infection. The goal is to improve therapeutic strategies that can effectively target and eliminate the virus, especially in patients with co-infections like HIV or hepatitis C. Patients may benefit from insights gained into more effective treatment options and potential cures for chronic hepatitis B.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments and potential cures for chronic hepatitis B infection.
How similar studies have gone: Previous research has shown promise in developing innovative treatments for hepatitis B, but this approach aims to provide novel insights that have not yet been fully explored.
Where this research is happening
-
Triad National Security, LLC
Los Alamos, United States Active
Researchers
- Principal investigator: Ribeiro, Ruy M — Triad National Security, LLC
- Study coordinator: Ribeiro, Ruy M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.