Understanding how heart injuries affect blood cell production
Mechanisms of myelopoiesis after myocardial infarction
This study is looking at how a heart injury, like a heart attack, causes your body to make more inflammatory blood cells and how this might affect your heart health, with the goal of finding new ways to help reduce any damage these cells might cause.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10625852 on NIH RePORTER |
What this research studies
This research investigates how a heart injury, like a heart attack, triggers the production of inflammatory blood cells in the bone marrow. It focuses on the signals and mechanisms that lead to this increased blood cell generation, particularly looking at how certain molecules in the blood after a heart attack influence stem cells in the bone marrow. By studying these processes, the research aims to uncover potential targets for therapies that could mitigate the harmful effects of these inflammatory cells on heart health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced a myocardial infarction and have related cardiovascular conditions.
Not a fit: Patients who have not had a myocardial infarction or do not have related cardiovascular issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce inflammation and improve recovery after heart attacks.
How similar studies have performed: Other research has shown promising results in understanding the role of inflammatory cells in cardiovascular diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Dutta, Partha — University of Pittsburgh at Pittsburgh
- Study coordinator: Dutta, Partha
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.