Understanding how heart cells mature for better heart function
Official title: Carm1-mediated transcriptional and posttranscriptional regulation of cardiomyocyte maturation
Funded at Univ of North Carolina Chapel Hill · NIH-11047363 · Data updated 2026-11-12
This study is looking at how heart cells grow and develop, especially focusing on a special enzyme called CARM1, to find ways to make these cells work better, which could help improve treatments for heart diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project start | January 1, 2025 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $751,747 |
| NIH project number | 1R01HL168285-01A1 |
| Project ID | NIH-11047363 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with heart disease or conditions affecting heart function, particularly those under 21 years old.
✕Less likely to help
Patients with fully mature cardiomyocytes or those without any heart-related conditions may not benefit from this research.
What this research studies
This research investigates the maturation process of cardiomyocytes, the heart's primary cells responsible for contraction. It aims to identify the molecular and functional changes that occur in these cells during their development, particularly focusing on the role of a specific enzyme called CARM1. By studying how CARM1 influences cardiomyocyte maturation, the research seeks to uncover potential pathways that could enhance heart cell function, which is crucial for treating heart diseases. The findings could lead to improved strategies for regenerative medicine and heart disease management.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance heart cell function and improve outcomes for patients with heart disease.
How similar studies have gone: Previous research has shown promising results in understanding cardiomyocyte maturation, but the specific role of CARM1 in this process is still largely untested.
Where this research is happening
-
Univ of North Carolina Chapel Hill
Chapel Hill, United States Active
Researchers
- Principal investigator: Liu, Jiandong — Univ of North Carolina Chapel Hill
- Study coordinator: Liu, Jiandong
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.