Understanding how gut microbes affect type 1 diabetes
Official title: Characterizing IgA-microbe interactions in type 1 diabetes
Funded at Washington University · NIH-11066050 · Data updated 2026-11-12
This study is looking at how a good bacteria called Akkermansia muciniphila in our gut might affect the immune system and play a role in the development of type 1 diabetes, with the hope of finding new ways to prevent or treat this condition.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $37,718 |
| NIH project number | 1F30DK142323-01 |
| Project ID | NIH-11066050 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk of developing type 1 diabetes, particularly children and adolescents.
✕Less likely to help
Patients who have already been diagnosed with type 1 diabetes and are not at risk for its development may not benefit from this research.
What this research studies
This research investigates the role of gut microbiota, specifically a beneficial bacterium called Akkermansia muciniphila, in the development of type 1 diabetes (T1D). The study aims to uncover how these microbes interact with the immune system, particularly focusing on the production of secretory IgA, which helps regulate microbial populations in the gut. By examining these interactions in both mice and human patients, the research seeks to clarify the mechanisms by which gut bacteria may influence the onset of T1D. This could lead to new insights into prevention or treatment strategies for this autoimmune disease.
Why it matters
Potential benefit: If successful, this research could lead to novel therapeutic approaches that harness gut microbiota to prevent or manage type 1 diabetes.
How similar studies have gone: Previous research has shown promising results regarding the role of gut microbiota in autoimmune diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Olin, Ilana Rae — Washington University
- Study coordinator: Olin, Ilana Rae
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.