Understanding how gut bacteria protect against infections
Host integration of commensal and pathogenic bacterial-derived signals
This work explores how beneficial gut bacteria communicate with our bodies to help protect against harmful bacterial infections, especially in children.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-11089419 on NIH RePORTER |
What this research studies
Our intestines are constantly interacting with many different types of bacteria, both good and bad. This project aims to discover how the cells lining our intestines understand signals from these bacteria to build defenses against infections. We are particularly interested in how helpful bacteria produce substances that can strengthen our body's protection. By using advanced models, including human intestinal organoids, we hope to uncover new ways to prevent and treat common gut infections.
Who could benefit from this research
Good fit: This foundational research focuses on understanding disease mechanisms, so it is not directly recruiting patients for participation at this time, but future clinical applications may benefit those with or at risk for enteric bacterial infections.
Not a fit: Patients not affected by or at risk for enteric bacterial infections would likely not receive direct benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that boost the body's natural defenses against serious bacterial infections, potentially reducing illness and improving health.
How similar studies have performed: While the specific mechanisms of how intestinal cells integrate microbial signals are not fully understood, other studies have shown the importance of gut microbiota in overall health and disease protection.
Where this research is happening
Cincinnati, United States
- Cincinnati Childrens Hosp Med Ctr — Cincinnati, United States (Active)
Researchers
- Principal investigator: Alenghat, Theresa — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Alenghat, Theresa
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.