Understanding how gut bacteria influence autoimmune diseases caused by trichloroethene exposure
Unraveling the contribution of gut microbiome in trichloroethene-mediated autoimmunity
This study is looking at how changes in gut bacteria might play a role in developing autoimmune diseases, like lupus, when people are exposed to a chemical called TCE, using mice to help understand this connection better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Med Br Galveston NIH-funded |
| Lab location | 1 site (Galveston, United States) |
| Project ID | NIH-10927562 on NIH RePORTER |
What this research studies
This research investigates the role of gut microbiome changes in the development of autoimmune diseases, specifically those triggered by exposure to trichloroethene (TCE). The study uses a mouse model to explore how TCE affects gut bacteria and immune responses, aiming to uncover the mechanisms that lead to autoimmune conditions like systemic lupus erythematosus (SLE). By analyzing fecal samples and the gut microbiota, the researchers hope to establish a connection between TCE exposure and autoimmune disease onset, which could lead to new prevention strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of exposure to trichloroethene and those with autoimmune diseases.
Not a fit: Patients who have not been exposed to trichloroethene or do not have autoimmune conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into preventing or treating autoimmune diseases linked to environmental exposures.
How similar studies have performed: Previous research has shown that environmental factors, including gut microbiome changes, can influence autoimmune diseases, suggesting that this approach has potential for success.
Where this research is happening
Galveston, United States
- University of Texas Med Br Galveston — Galveston, United States (Active)
Researchers
- Principal investigator: Khan, M. Firoze — University of Texas Med Br Galveston
- Study coordinator: Khan, M. Firoze
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.