Understanding how gut bacteria help the immune system fight viruses.
Defining the role of microbiota-derived cyclic dinucleotides in priming antiviral immune defenses.
This study is looking at how the bacteria in our gut can help our immune system fight off viral infections, especially as we get older, and it aims to find new ways to improve treatments for these infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10767865 on NIH RePORTER |
What this research studies
This research investigates how the bacteria in our gut can influence our immune response to viral infections, particularly as we age. It focuses on the role of specific molecules produced by these bacteria that may help prime our immune defenses. By studying the interactions between gut microbiota and immune cells, the research aims to uncover new strategies for treating viral infections that affect the gastrointestinal tract. The approach includes developing models to better understand these complex interactions and their implications for health.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults who may be more susceptible to gastrointestinal viral infections.
Not a fit: Patients with non-viral gastrointestinal diseases or those not affected by aging-related immune decline may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance the immune response against viral infections in the gut.
How similar studies have performed: Previous research has shown that gut microbiota can influence immune responses, suggesting that this approach may yield valuable insights.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Cherry, Sara — University of Pennsylvania
- Study coordinator: Cherry, Sara
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.