Understanding how gut bacteria can influence immune responses
Decode and design T cell induction by a complex gut microbial community
['FUNDING_CAREER'] · STANFORD UNIVERSITY · NIH-10885910
This study is looking at how certain types of gut bacteria can help boost the immune system to fight diseases like cancer and autoimmune disorders, and it's aimed at finding new treatments that use the good bacteria in our guts to improve health.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STANFORD UNIVERSITY (nih funded) |
| Locations | 1 site (STANFORD, UNITED STATES) |
| Trial ID | NIH-10885910 on ClinicalTrials.gov |
What this research studies
This research investigates how specific strains of gut bacteria can stimulate the immune system to produce targeted T and B cells, which are crucial for fighting diseases like cancer and autoimmune disorders. By creating a complex gut environment in germ-free mice, the researchers will analyze how these bacteria interact with immune cells. The goal is to uncover the mechanisms behind these interactions to develop new therapies that harness the power of the gut microbiome for better health outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with autoimmune diseases, cancer, or other conditions that could benefit from improved immune modulation.
Not a fit: Patients who do not have immune-related conditions or those who are not responsive to microbial therapies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that enhance the immune response against various diseases.
How similar studies have performed: Previous research has shown promise in using gut microbiota to modulate immune responses, indicating that this approach could be effective.
Where this research is happening
STANFORD, UNITED STATES
- STANFORD UNIVERSITY — STANFORD, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: NAGASHIMA, KAZUKI — STANFORD UNIVERSITY
- Study coordinator: NAGASHIMA, KAZUKI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autoimmune Diseases