Understanding how gut bacteria affect heart health
Official title: Interrogating function, regulation, and interactions in a clade of prevalent human gut microbes
Funded at Ohio State University · NIH-11092893 · Data updated 2026-11-12
This study is looking at how certain gut bacteria might affect heart health, especially for people with atherosclerosis, to see if changes in diet or treatments could help improve their condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | August 1, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $381,621 |
| NIH project number | 5R35GM151155-03 |
| Project ID | NIH-11092893 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for atherosclerosis or those with cardiovascular disease who are interested in the role of gut health in their condition.
✕Less likely to help
Patients who do not have any cardiovascular risk factors or gut health issues may not receive direct benefits from this research.
What this research studies
This research investigates the role of specific gut bacteria in influencing heart health, particularly in relation to atherosclerosis. By examining how these bacteria metabolize different nutrients and interact with each other, the study aims to uncover the biochemical processes that link gut microbiota to cardiovascular disease. The research employs a combination of computational and experimental methods to analyze gene functions and metabolic outputs of prevalent gut bacteria, specifically focusing on the Bacteroidales group. Patients may benefit from insights that could lead to new dietary or therapeutic interventions targeting gut bacteria to improve heart health.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating atherosclerosis through dietary or microbiome-based interventions.
How similar studies have gone: Previous research has shown promising results in understanding the link between gut microbiota and cardiovascular health, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Bradley, Patrick Joseph — Ohio State University
- Study coordinator: Bradley, Patrick Joseph
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.