Understanding how GPR34 affects immune cell movement and function in cancer
Official title: Dissecting the role of GPR34 in cDC1 migration and function
Funded at University of California, San Francisco · NIH-10912531 · Data updated 2026-11-12
This study is looking at how a special receptor called GPR34 helps certain immune cells, which are key in fighting cancer and infections, move to where they are needed most, like inflamed areas and tumors, to see if this can lead to better cancer treatments.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $41,324 |
| NIH project number | 5F30CA284515-02 |
| Project ID | NIH-10912531 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with cancers that may involve immune system interactions, particularly those with colon or ovarian cancer.
✕Less likely to help
Patients with non-cancerous conditions or those not involving immune system modulation may not benefit from this research.
What this research studies
This research investigates the role of a specific receptor, GPR34, in the movement and function of immune cells called type 1 conventional dendritic cells (cDC1s), which are important for fighting cancer and infections. The study will explore how GPR34 influences the migration of these cells to areas of inflammation and tumors, potentially affecting their ability to present antigens to CD8+ T cells. By examining these processes in detail, the research aims to uncover new insights into how the immune system can be harnessed to improve cancer treatment.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing immune responses against cancer.
How similar studies have gone: Other research has shown promising results in understanding immune cell migration and function, making this approach both relevant and potentially impactful.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Tam, Hanson Peter — University of California, San Francisco
- Study coordinator: Tam, Hanson Peter
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.