Understanding how GPCR regulators (RGS) control platelet function
Official title: Characterization of RGS Function and Signaling
Funded at Texas A&m University Health Science Ctr · NIH-11387365 · Data updated 2026-11-12
Researchers are studying how specific regulators called RGS proteins affect how platelets respond, which could influence clotting in conditions like sepsis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas A&m University Health Science Ctr NIH-funded |
| Lab location | 1 site (College Station, United States) |
| Project start | August 15, 2026 |
| Project end | May 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $761,981 |
| NIH project number | 1R01HL182020-01A1 |
| Project ID | NIH-11387365 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not specified in this grant; preclinical studies using human-derived cells or models may be involved, but direct patient enrollment is not described.
✕Less likely to help
No direct patient benefits described at this stage, as the work is mechanistic and preclinical.
What this research studies
This project will look at how RGS proteins (RGS10, RGS16, and RGS18) regulate platelet signaling and aggregation, including under conditions that mimic sepsis. The work will map when these proteins are activated or modified by phosphorylation, and how they influence both activating and inhibitory pathways in platelets. By using targeted experiments, the team aims to uncover mechanistic details that could identify new ways to modulate platelet responses. The findings could inform future therapies to prevent abnormal clotting without compromising normal healing.
Why it matters
Potential benefit: A clearer picture of platelet regulation could lead to new approaches to prevent sepsis-related thrombosis and related clotting disorders.
How similar studies have gone: Prior studies on RGS proteins in platelets exist but are limited and mostly correlative; this project seeks to provide deeper mechanistic insights.
Where this research is happening
-
Texas A&m University Health Science Ctr
College Station, United States Active
Researchers
- Principal investigator: Khasawneh, Fadi T — Texas A&m University Health Science Ctr
- Study coordinator: Khasawneh, Fadi T
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.