Understanding how glypicans help fight bacterial lung infections
Official title: Glypicans in Bacterial Lung Infection
Funded at Boston Children's Hospital · NIH-11064010 · Data updated 2026-11-12
This study is looking at how certain proteins in our lungs help fight off bacterial infections, with the goal of finding new ways to keep our lungs healthy and prevent infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $561,477 |
| NIH project number | 5R01HL161605-02 |
| Project ID | NIH-11064010 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults suffering from acute respiratory distress syndrome or bacterial pneumonia.
✕Less likely to help
Patients with non-bacterial lung infections or those who do not have respiratory distress may not benefit from this research.
What this research studies
This research investigates the role of glypicans, a type of protein found on cell surfaces, in protecting the lungs from bacterial infections. It aims to uncover how these proteins help the body clear bacteria and prevent them from invading lung tissues. The study will explore the interactions between glypicans and bacteria, particularly focusing on how these proteins may enhance the immune response and support lung health. By examining these mechanisms, the research hopes to provide insights into new therapeutic strategies for lung infections.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance the body's ability to fight bacterial lung infections, potentially improving outcomes for patients with respiratory diseases.
How similar studies have gone: Previous research has shown that understanding the role of cell surface proteins in immune responses can lead to significant advancements in treating infections, suggesting this approach has potential for success.
Where this research is happening
-
Boston Children's Hospital
Boston, United States Active
Researchers
- Principal investigator: Park, Pyong Woo — Boston Children's Hospital
- Study coordinator: Park, Pyong Woo
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.