Understanding how glucose affects intestinal stem cells
Official title: The Role of GLUT1 and Glucose in Intestinal Stem Cell Homeostasis and Regeneration
Funded at Massachusetts General Hospital · NIH-10980981 · Data updated 2026-11-12
This study is looking at how certain proteins help intestinal stem cells take in sugar, which could help us understand how to keep our intestines healthy and support their healing.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | July 17, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $631,208 |
| NIH project number | 1R01DK138040-01A1 |
| Project ID | NIH-10980981 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions affecting intestinal health, such as diabetes or gastrointestinal disorders.
✕Less likely to help
Patients without any gastrointestinal issues or metabolic disorders may not benefit from this research.
What this research studies
This research investigates the role of glucose transporters in the health and regeneration of intestinal stem cells (ISCs). It aims to identify which glucose transporters are involved in the uptake of glucose by ISCs, as current knowledge is limited. By studying transgenic mice, the research will explore how glucose influences ISC behavior and adaptation to different metabolic conditions. This could lead to a better understanding of how glucose impacts intestinal health and regeneration.
Why it matters
Potential benefit: If successful, this research could improve treatments for conditions related to intestinal health and regeneration.
How similar studies have gone: While the role of glucose in other cell types has been studied, this specific investigation into ISCs is relatively novel and untested.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Saeidi, Nima — Massachusetts General Hospital
- Study coordinator: Saeidi, Nima
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.