Understanding how gliomas evolve and adapt at the cellular level
Deciphering heritability, plasticity and differentiation trajectories in gliomas via single-cell multi-omics
This study is looking at how gliomas, a type of brain cancer, grow and change over time by exploring the genes and surroundings of the tumor cells, with the goal of finding better ways to treat patients and prevent the cancer from coming back.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11059190 on NIH RePORTER |
What this research studies
This research investigates the complex evolution of gliomas, a type of brain cancer, by examining the genetic and environmental factors that influence tumor cell behavior. Using advanced single-cell sequencing technologies, the study aims to identify the different cellular states and their roles in tumor growth and resistance to treatment. By analyzing how these cells change over time, the research seeks to uncover the mechanisms behind glioma recurrence and develop strategies to improve treatment outcomes for patients.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with gliomas who are undergoing treatment or have experienced recurrence of the disease.
Not a fit: Patients with other types of brain tumors or those who are not diagnosed with gliomas may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for glioma patients by targeting the specific cellular mechanisms that drive tumor growth and resistance.
How similar studies have performed: Other research has shown promise in using single-cell sequencing to understand cancer evolution, indicating that this approach could yield valuable insights into gliomas as well.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Suva, Mario Luca — Massachusetts General Hospital
- Study coordinator: Suva, Mario Luca
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.