Understanding how glioblastoma brain cancer becomes resistant to radiation treatment
Official title: Targeting Adaptive Radioresistance of Glioblastoma
Funded at University of Alabama at Birmingham · NIH-11013836 · Data updated 2026-11-12
This study is looking into how glioblastoma, a tough type of brain cancer, manages to survive radiation treatment, with the hope of finding new ways to make the treatment more effective for patients like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project start | January 1, 2023 |
| Project end | December 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $108,000 |
| NIH project number | 5K22CA263305-03 |
| Project ID | NIH-11013836 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with glioblastoma, particularly those who have undergone radiation therapy.
✕Less likely to help
Patients with other types of brain tumors or those who have not received radiation therapy may not benefit from this research.
What this research studies
This research investigates the mechanisms that allow glioblastoma, a deadly brain cancer, to survive radiation therapy. By developing advanced models that mimic the genetic diversity of glioblastoma, including its stem cells, the research aims to uncover why some cancer cells resist treatment. The study employs innovative techniques like CRISPR screening to identify genes associated with radioresistance, potentially leading to new therapies that can overcome this challenge. Patients may benefit from insights that could improve treatment strategies for glioblastoma.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for glioblastoma, improving survival rates and quality of life for patients.
How similar studies have gone: Previous research has shown promise in targeting radioresistance in cancer, but this specific approach focusing on glioblastoma and its stem cells is relatively novel.
Where this research is happening
-
University of Alabama at Birmingham
Birmingham, United States Active
Researchers
- Principal investigator: Osuka, Satoru — University of Alabama at Birmingham
- Study coordinator: Osuka, Satoru
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.