Understanding how germ cells develop in mammalian ovaries
Official title: Quantifying germ cell lineage dynamics in mammalian oogenesis
Funded at University of California, San Francisco · NIH-11069762 · Data updated 2026-11-12
This study is looking at how the cells that develop into eggs in women are chosen and how some of them don’t make it, which could help us understand fertility issues, especially for those facing early menopause or age-related challenges.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | December 1, 2024 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $41,750 |
| NIH project number | 1F30HD117592-01 |
| Project ID | NIH-11069762 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with ovaries experiencing infertility issues, particularly those aged 15-44.
✕Less likely to help
Patients who do not have fertility concerns or are outside the reproductive age range may not benefit from this research.
What this research studies
This research investigates the dynamics of germ cell lineages during the development of mammalian oocytes, which are crucial for female fertility. By examining how these cells are selected based on their quality and characteristics, the study aims to uncover the mechanisms behind oocyte attrition and the formation of the ovarian reserve. The approach involves advanced techniques such as CRISPR technology to analyze cellular behaviors and responses during early development. This research could provide insights into the factors affecting fertility, particularly in cases of premature ovarian insufficiency and age-related fertility decline.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential treatments for infertility in individuals with ovaries.
How similar studies have gone: Previous research has shown promise in understanding germ cell dynamics, but this specific approach using CRISPR technology is relatively novel.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Zussman, Jay Wolf — University of California, San Francisco
- Study coordinator: Zussman, Jay Wolf
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.