Understanding how genetics, sex, and environment affect autoimmune diseases in the nervous system.
Novel mouse models to dissect the role of genetics, sex, and environment in heterogeneous outcomes in CNS autoimmune disease
This study is looking at how different things like genes, gender, and the environment affect how multiple sclerosis (MS) progresses and impacts people, using special mouse models to help us understand these factors better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Vermont & St Agric College NIH-funded |
| Lab location | 1 site (Burlington, United States) |
| Project ID | NIH-10884448 on NIH RePORTER |
What this research studies
This research investigates the complex factors that contribute to the varying outcomes of central nervous system autoimmune diseases, particularly multiple sclerosis (MS). By utilizing novel mouse models, the study aims to dissect the roles of genetics, sex differences, and environmental influences on disease progression and severity. The research will explore how these factors interact and contribute to the immune system's attack on the nervous system, which leads to neurological disabilities. The findings could provide insights that are difficult to obtain from human studies alone.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with multiple sclerosis or those at risk due to genetic factors.
Not a fit: Patients with autoimmune diseases unrelated to the central nervous system may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with multiple sclerosis and similar autoimmune diseases.
How similar studies have performed: While there have been studies on multiple sclerosis, this approach using novel mouse models to dissect genetic and environmental interactions is relatively novel.
Where this research is happening
Burlington, United States
- University of Vermont & St Agric College — Burlington, United States (Active)
Researchers
- Principal investigator: Krementsov, Dimitry N — University of Vermont & St Agric College
- Study coordinator: Krementsov, Dimitry N
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.