Understanding how genetics influence immune responses to infections across different populations
Official title: Characterizing the genetic and evolutionary determinants of population variation in transcriptional responses to pathogens
Funded at University of Chicago · NIH-11136220 · Data updated 2026-11-12
This study looks at how our genes and history affect how different people’s immune systems respond to infections, helping us understand why some folks might get sick more easily than others based on their background.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | July 10, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $517,611 |
| NIH project number | 5R35GM152227-02 |
| Project ID | NIH-11136220 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals from diverse ancestry backgrounds who are interested in understanding their immune response to infections.
✕Less likely to help
Patients with no genetic diversity or those not affected by infectious diseases may not benefit from this research.
What this research studies
This research investigates how genetic and evolutionary factors shape the immune responses of various human populations to pathogens. By examining gene expression and epigenetic traits, the study aims to identify genetic variants that contribute to differences in immune responses among diverse ancestry groups. The research will analyze how natural selection and genetic ancestry influence these immune responses, providing insights into the evolution of the human immune system. Patients may benefit from a better understanding of how their genetic background affects their susceptibility to infections.
Why it matters
Potential benefit: If successful, this research could lead to personalized approaches in treating infections based on genetic backgrounds.
How similar studies have gone: Other research has shown success in understanding genetic influences on immune responses, making this approach promising.
Where this research is happening
-
University of Chicago
Chicago, United States Active
Researchers
- Principal investigator: Barreiro, Luis Bruno — University of Chicago
- Study coordinator: Barreiro, Luis Bruno
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.