Understanding how genetics and social experiences affect mental health
Neurogenomics of Vulnerability and Resilience to Mental Health Syndromes in Response to Extreme Life Events
This study looks at how genes and social support affect mental health in monkeys who experience tough life events, helping us learn more about how these factors might impact people too.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10661680 on NIH RePORTER |
What this research studies
This research investigates the genetic and biological factors that contribute to mental health issues in response to extreme life events. By studying free-ranging rhesus macaques, researchers aim to understand how social support and vulnerability influence mental health outcomes. The study utilizes advanced sequencing technologies to explore the connections between genetics, social behavior, and brain function. This approach offers insights that could lead to better understanding and treatment of mental health syndromes in humans.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced extreme life events and are at risk for mental health syndromes.
Not a fit: Patients who have not experienced significant life stressors or do not have mental health concerns may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and treating mental health disorders by identifying genetic and social factors that contribute to resilience and vulnerability.
How similar studies have performed: Previous research has shown success in using animal models to understand mental health, but this study's focus on nonhuman primates offers a novel approach that may yield unique insights.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Platt, Michael L — University of Pennsylvania
- Study coordinator: Platt, Michael L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.