Understanding how genetics and metabolism affect aspirin effectiveness
Official title: Integration of Pharmacogenomics and Metabolomics in the Study of Antiplatelet Efficacy
Funded at University of Maryland Baltimore · NIH-10997427 · Data updated 2026-11-12
This study is looking at how your unique genes and metabolism might affect how well aspirin and similar medications work to prevent blood clots in people with heart issues, so we can find better ways to tailor treatments just for you.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | December 15, 2023 |
| Project end | November 30, 2025 |
| Funding year | 2025 |
| Award (this year) | $116,625 |
| NIH project number | 5R21HL172155-02 |
| Project ID | NIH-10997427 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with acute coronary syndrome who are prescribed aspirin or similar antiplatelet medications.
✕Less likely to help
Patients who are not taking antiplatelet medications or do not have acute coronary syndrome may not benefit from this research.
What this research studies
This research investigates how individual genetic differences and metabolic profiles influence the effectiveness of aspirin and similar medications in preventing blood clots in patients with acute coronary syndrome. By analyzing data from participants in a previous study, researchers will look for new biomarkers that could explain why some patients respond better to these treatments than others. The study involves collecting genetic information, measuring drug levels, and assessing platelet function to gain insights into personalized treatment approaches.
Why it matters
Potential benefit: If successful, this research could lead to more personalized and effective treatment strategies for patients at risk of cardiovascular events.
How similar studies have gone: Previous research has shown promise in using pharmacogenomics and metabolomics to tailor medication strategies, indicating potential for success in this approach.
Where this research is happening
-
University of Maryland Baltimore
Baltimore, United States Active
Researchers
- Principal investigator: Lewis, Joshua Patrick — University of Maryland Baltimore
- Study coordinator: Lewis, Joshua Patrick
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.