Understanding how genetics and metabolism affect aspirin effectiveness
Integration of Pharmacogenomics and Metabolomics in the Study of Antiplatelet Efficacy
This study is looking at how your unique genes and metabolism might affect how well aspirin and similar medications work to prevent blood clots in people with heart issues, so we can find better ways to tailor treatments just for you.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10997427 on NIH RePORTER |
What this research studies
This research investigates how individual genetic differences and metabolic profiles influence the effectiveness of aspirin and similar medications in preventing blood clots in patients with acute coronary syndrome. By analyzing data from participants in a previous study, researchers will look for new biomarkers that could explain why some patients respond better to these treatments than others. The study involves collecting genetic information, measuring drug levels, and assessing platelet function to gain insights into personalized treatment approaches.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with acute coronary syndrome who are prescribed aspirin or similar antiplatelet medications.
Not a fit: Patients who are not taking antiplatelet medications or do not have acute coronary syndrome may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more personalized and effective treatment strategies for patients at risk of cardiovascular events.
How similar studies have performed: Previous research has shown promise in using pharmacogenomics and metabolomics to tailor medication strategies, indicating potential for success in this approach.
Where this research is happening
Baltimore, United States
- University of Maryland Baltimore — Baltimore, United States (Active)
Researchers
- Principal investigator: Lewis, Joshua Patrick — University of Maryland Baltimore
- Study coordinator: Lewis, Joshua Patrick
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.