Understanding how genetics affects lipoprotein(a) levels and cardiovascular health in different populations
Official title: Unraveling the Genetic Basis and Cardiovascular Impact of Lipoprotein(a) in Diverse Populations
Funded at Philadelphia VA Medical Center · NIH-10918572 · Data updated 2026-11-12
This study is looking at how our genes affect the levels of lipoprotein(a), which is important for heart health, especially for people at risk of heart disease, like those in the Black community, to help find new treatments that could lower these levels and improve heart health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Philadelphia VA Medical Center NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2025 |
| NIH project number | 1IK2BX006551-01 |
| Project ID | NIH-10918572 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals from diverse backgrounds, particularly those in the Black population who have elevated Lp(a) levels and are at risk for ASCVD.
✕Less likely to help
Patients who do not have elevated Lp(a) levels or those not at risk for atherosclerotic cardiovascular disease may not benefit from this research.
What this research studies
This research investigates the genetic factors that influence levels of lipoprotein(a) [Lp(a)], a key risk factor for atherosclerotic cardiovascular disease (ASCVD), particularly in diverse populations. By analyzing genetic data from over 350,000 individuals, including those from the Black population who are disproportionately affected by ASCVD, the study aims to identify how genetic variations impact Lp(a) levels and subsequent cardiovascular outcomes. The findings could help pinpoint individuals who may benefit from new therapies aimed at lowering Lp(a).
Why it matters
Potential benefit: If successful, this research could lead to personalized treatment strategies for individuals at high risk of cardiovascular disease due to elevated Lp(a) levels.
How similar studies have gone: Previous research has shown promising results in understanding genetic factors related to cardiovascular disease, indicating that this approach could yield valuable insights.
Where this research is happening
-
Philadelphia VA Medical Center
Philadelphia, United States Active
Researchers
- Principal investigator: Levin, Michael G — Philadelphia VA Medical Center
- Study coordinator: Levin, Michael G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.