Understanding how genetics affect smoking-related blood vessel problems
Official title: Delineating the Genetic Susceptibility of Smoking-Induced Vascular Dysfunction
Funded at University of Utah · NIH-10895572 · Data updated 2026-11-12
This study is looking at how our genes might affect how smoking impacts heart health, and it’s designed to help people understand their own risks related to smoking and heart problems.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $249,000 |
| NIH project number | 5R00HL150319-04 |
| Project ID | NIH-10895572 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a history of smoking or those at risk for cardiovascular diseases due to smoking.
✕Less likely to help
Patients who have never smoked and do not have a genetic predisposition to cardiovascular diseases may not benefit from this research.
What this research studies
This research investigates how genetic differences among individuals influence their susceptibility to cardiovascular issues caused by smoking. The project utilizes advanced techniques in bioinformatics and drug discovery, alongside insights from environmental health and immunology. Patients may benefit from a better understanding of their own genetic risks related to smoking and cardiovascular health. The research is led by Dr. Hongchao Guo, who is being mentored by experts in cardiovascular disease and immune dysfunction.
Why it matters
Potential benefit: If successful, this research could lead to personalized strategies for preventing smoking-related cardiovascular diseases based on genetic profiles.
How similar studies have gone: Previous research has shown promise in understanding genetic factors in cardiovascular diseases, indicating that this approach could yield valuable insights.
Where this research is happening
-
University of Utah
Salt Lake City, United States Active
Researchers
- Principal investigator: Guo, Hongchao — University of Utah
- Study coordinator: Guo, Hongchao
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.