Understanding how genetics affect immune responses to COVID-19
Official title: Immunogenetics of COVID-19 Immune Response
Funded at Mayo Clinic Rochester · NIH-10988035 · Data updated 2026-11-12
This study is looking at how our genes might affect how we respond to COVID-19 and its vaccines, so we can better understand who might need different kinds of protection and help create more personalized vaccination plans.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $814,873 |
| NIH project number | 1R01AI179709-01A1 |
| Project ID | NIH-10988035 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who have been vaccinated against COVID-19 or have had a COVID-19 infection.
✕Less likely to help
Patients who have not been vaccinated or infected with COVID-19 may not benefit from this research.
What this research studies
This research investigates the genetic factors that influence how individuals respond to COVID-19 infections and vaccinations. By examining variations in genes and their associations with immune responses, the study aims to identify specific genetic markers that could predict how well a person will respond to the virus or a vaccine. The approach includes comprehensive genome-wide association studies (GWAS) and phenome-wide association studies (PheWAS) to uncover the complex interactions between genetics and immune response. This research could lead to personalized vaccination strategies and improved understanding of immunity against COVID-19.
Why it matters
Potential benefit: If successful, this research could lead to more effective vaccines and treatments tailored to individual genetic profiles.
How similar studies have gone: Previous research has successfully identified genetic factors influencing immune responses to other viral vaccines, suggesting a promising avenue for similar findings in COVID-19.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Kennedy, Richard B — Mayo Clinic Rochester
- Study coordinator: Kennedy, Richard B
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.