Understanding how genetics affect gut immunity to fight bacterial infections
Role of Epigenetics and their Pharmacological Modulators in Innate Intestinal Immunity and Adjuvanticity in Humans
This research explores how changes in our genes, called epigenetics, influence our gut's natural defenses to help us better fight off bacterial infections.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11173650 on NIH RePORTER |
What this research studies
Our bodies have a natural defense system in the gut that protects us from harmful bacteria. This project looks at how small changes in our genes, called epigenetics, affect this defense system. Researchers are exploring how certain medicines could adjust these genetic changes to strengthen our immune memory, potentially offering better protection against common gut infections like Salmonella and Shigella. The goal is to find new ways to boost our body's ability to fight off a wide range of bacteria.
Who could benefit from this research
Good fit: This research focuses on human intestinal immunity, particularly in adults and children, and those susceptible to or affected by bacterial infections like Salmonella and Shigella.
Not a fit: Patients whose conditions are unrelated to bacterial infections or intestinal immunity would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new strategies for developing vaccines and treatments that enhance our natural immunity against various bacterial infections.
How similar studies have performed: This project builds upon the researchers' previous findings regarding specific immune cells, suggesting a foundation of prior work in this area.
Where this research is happening
Baltimore, United States
- University of Maryland Baltimore — Baltimore, United States (Active)
Researchers
- Principal investigator: Mezghanni, Rosangela — University of Maryland Baltimore
- Study coordinator: Mezghanni, Rosangela
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.