Understanding how genetic variations affect disease in different ancestries
Official title: Identifying ancestry-specific and distal components of disease-associated gene regulation and cellular function
Funded at University of California, San Diego · NIH-10943180 · Data updated 2026-11-12
This study is looking at how certain genetic differences can affect diseases, especially in people from non-European backgrounds, to help find important genes and improve treatments for everyone.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | September 4, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $491,366 |
| NIH project number | 1R01HG013671-01 |
| Project ID | NIH-10943180 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals from diverse ancestral backgrounds who have been diagnosed with diseases linked to genetic variations.
✕Less likely to help
Patients with diseases that are not influenced by genetic variations or those from homogeneous genetic backgrounds may not benefit from this research.
What this research studies
This research investigates how specific genetic variations influence diseases by focusing on noncoding DNA sequences that regulate gene expression. It aims to identify disease-critical genes linked to these variations, particularly in non-European populations where data is limited. By developing advanced algorithms, the study will map these genetic variants to their target genes and explore how they function in different cell types. This approach could lead to a better understanding of the mechanisms behind various diseases and inform the development of targeted therapies.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments tailored to the genetic backgrounds of diverse patient populations.
How similar studies have gone: Previous studies have successfully identified genetic associations with diseases using similar methodologies, indicating a promising potential for this research.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Amariuta-Bartell, Tiffany — University of California, San Diego
- Study coordinator: Amariuta-Bartell, Tiffany
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.