Understanding how genetic variations affect complex health traits
Official title: Genome evolution across complex trait hierarchies
Funded at University of Missouri-Columbia · NIH-11061367 · Data updated 2026-11-12
This study is looking at how different genes work together to affect health traits like energy use and heart disease, using fruit flies to help us understand these connections better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Missouri-Columbia NIH-funded |
| Lab location | 1 site (Columbia, United States) |
| Project start | May 1, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $384,364 |
| NIH project number | 5R35GM149238-03 |
| Project ID | NIH-11061367 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a family history of complex traits like coronary artery disease or those interested in the genetic factors affecting their health.
✕Less likely to help
Patients with simple genetic disorders or those not affected by complex traits may not benefit from this research.
What this research studies
This research investigates the intricate relationships between genetic variants and complex health traits, such as energy expenditure and coronary artery disease. By using fruit flies as a model organism, the project aims to identify how multiple genetic factors interact with each other and environmental influences to shape these traits. The researchers will evolve these flies while tracking changes in their genetics and physical characteristics, providing insights into the underlying mechanisms of complex traits. This innovative approach seeks to bridge the knowledge gap in understanding the genetic basis of health conditions.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for complex health conditions influenced by genetic factors.
How similar studies have gone: Previous research has shown success in using model organisms to uncover genetic interactions, suggesting that this approach has the potential for meaningful discoveries.
Where this research is happening
-
University of Missouri-Columbia
Columbia, United States Active
Researchers
- Principal investigator: King, Elizabeth Griep — University of Missouri-Columbia
- Study coordinator: King, Elizabeth Griep
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.