Understanding how genetic variations affect behavior in neuropsychiatric disorders.
Official title: 6/9: Dissecting the effects of genomic variants on neurobehavioral dimensions in CNVs enriched for neuropsychiatric disorders.
Funded at Sainte-Justine University Hospital Ctr · NIH-10811617 · Data updated 2026-11-12
This study is looking at how certain genetic changes might affect behaviors related to mental health issues like anxiety and attention disorders, and it's designed for people with known genetic conditions to help us better understand the link between genes and mental health.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sainte-Justine University Hospital Ctr NIH-funded |
| Lab location | 1 site (Montreal, Canada) |
| Project start | April 1, 2020 |
| Project end | March 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $104,923 |
| NIH project number | 5U01MH119739-05 |
| Project ID | NIH-10811617 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with neuropsychiatric disorders linked to specific genetic variants, particularly those with 22q11.2 and 16p11.2 CNVs.
✕Less likely to help
Patients without neuropsychiatric disorders or those not carrying the specific genetic variants being studied may not benefit from this research.
What this research studies
This research investigates the impact of specific genetic variations, known as copy number variants (CNVs), on neurobehavioral traits associated with various psychiatric disorders. By focusing on patients with known genetic conditions, the study aims to clarify how these genetic factors contribute to a range of mental health issues, including anxiety and attention disorders. The research employs a combination of genetic analysis and behavioral assessments to build predictive models of risk for these conditions. This approach seeks to enhance our understanding of the complex interplay between genetics and environmental influences on mental health.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnosis and treatment strategies for individuals with neuropsychiatric disorders.
How similar studies have gone: Previous research has shown promising results in understanding the genetic basis of neuropsychiatric disorders, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Sainte-Justine University Hospital Ctr
Montreal, Canada Active
Researchers
- Principal investigator: Jacquemont, Sebastien — Sainte-Justine University Hospital Ctr
- Study coordinator: Jacquemont, Sebastien
Related research
Other NIH-funded projects on the same topics.
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Understanding how rare genetic changes affect brain and risk for neurodevelopmental disorders
A large study will look at people with specific rare genetic changes to see how these affect brain structure, brain activity, and behavior, with the goal of linking genetic variants to ADHD, autism, and other brain disorders.
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Understanding Rare Genetic Variations and Brain Health Across ADHD and Autism
Researchers will study how rare genetic changes affect brain structure and function in people with neurodevelopmental conditions like ADHD and autism, using a large international dataset.
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Exploring how rare genetic variations affect brain structure and mental health risks.
This study is looking at how certain genetic changes might affect brain development and behavior in people with neurodevelopmental psychiatric disorders, and it's for anyone interested in understanding the links between genetics and mental health.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.