Understanding how genetic variations affect behavior in neuropsychiatric disorders.
2/9: Dissecting the effects of genomic variants on neurobehavioral dimensions in CNVs enriched for neuropsychiatric disorders.
This study is looking at how certain genetic changes might affect behaviors and mental health in people with known genetic conditions, like anxiety and attention disorders, to help us better understand these issues and improve ways to predict who might be at risk.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10596622 on NIH RePORTER |
What this research studies
This research investigates the impact of specific genetic variations, known as copy number variants (CNVs), on neurobehavioral traits associated with neuropsychiatric disorders. By focusing on patients with known genetic conditions, the study aims to clarify how these genetic factors contribute to a range of mental health issues, including anxiety and attention disorders. The research employs a genetics-first approach, analyzing both the main effects of CNVs and the influence of other genetic and environmental factors on mental health outcomes. This comprehensive analysis seeks to improve understanding of the genetic underpinnings of psychiatric conditions and enhance risk prediction models.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with neuropsychiatric disorders who have known genetic variants, particularly those related to the 22q11.2 and 16p11.2 loci.
Not a fit: Patients without identifiable genetic variants or those with idiopathic neuropsychiatric disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better diagnosis and treatment strategies for patients with neuropsychiatric disorders based on their genetic profiles.
How similar studies have performed: Previous research has shown promising results in understanding the genetic basis of neuropsychiatric disorders, suggesting that this approach could yield valuable insights.
Where this research is happening
Philadelphia, United States
- Children's Hosp of Philadelphia — Philadelphia, United States (Active)
Researchers
- Principal investigator: Mcdonald-Mcginn, Donna Marie — Children's Hosp of Philadelphia
- Study coordinator: Mcdonald-Mcginn, Donna Marie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.