Understanding how genetic variation affects host-parasite interactions
Official title: Evolutionary Systems Biology of Host-Parasite Interactions
Funded at University of California Riverside · NIH-11086010 · Data updated 2026-11-12
This study is looking at how our genes affect the way our bodies fight off certain parasites, like worms, and how these parasites try to outsmart our immune system, which could help us understand why some people get sick while others don’t.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Riverside NIH-funded |
| Lab location | 1 site (Riverside, United States) |
| Project start | August 1, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $378,584 |
| NIH project number | 5R35GM151194-03 |
| Project ID | NIH-11086010 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic variations that may influence their immune response to parasitic infections.
✕Less likely to help
Patients who do not have any genetic predisposition to parasitic infections or those who are not affected by such conditions may not benefit from this research.
What this research studies
This research investigates the genetic factors that influence how hosts and parasites interact, particularly focusing on parasitic helminths like nematodes. By examining how natural selection shapes genetic variation in these interactions, the study aims to uncover the underlying genetic architecture that determines host resistance and parasite evasion strategies. The approach includes analyzing genomic data and identifying key traits that affect these dynamics, with the goal of understanding how these traits evolve over time. This research could provide insights into the mechanisms of disease resistance and susceptibility in various populations.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for managing and preventing infections caused by parasitic helminths.
How similar studies have gone: Previous research has shown success in understanding host-parasite dynamics through genetic analysis, indicating that this approach has potential for significant findings.
Where this research is happening
-
University of California Riverside
Riverside, United States Active
Researchers
- Principal investigator: Groen, Simon Cornelis — University of California Riverside
- Study coordinator: Groen, Simon Cornelis
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.