Understanding how genetic factors influence Lp(a) levels and cardiovascular risk
Unraveling the Complexities of Lp(a): From Genes to Function
['FUNDING_R01'] · COLUMBIA UNIVERSITY HEALTH SCIENCES · NIH-10827089
This study is looking at how certain genes affect levels of Lipoprotein(a), a substance linked to heart disease, especially in Black and Hispanic people, to help find better treatments for those at risk.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | COLUMBIA UNIVERSITY HEALTH SCIENCES (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10827089 on ClinicalTrials.gov |
What this research studies
This research investigates the role of Lipoprotein(a) [Lp(a)] in cardiovascular disease, particularly focusing on how genetic variations affect Lp(a) levels among different ethnic groups. By analyzing a diverse cohort at Columbia University Medical Center, the study aims to identify specific genetic markers that contribute to higher Lp(a) levels in Black and Hispanic populations. Advanced technologies will be employed to characterize the Lp(a) particles and their functions, providing insights into their role in cardiovascular risk. The findings could lead to better-targeted therapies for those at risk due to high Lp(a) levels.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals from Black and Hispanic backgrounds who have elevated Lp(a) levels and are at risk for cardiovascular disease.
Not a fit: Patients who do not have elevated Lp(a) levels or belong to ethnic groups with lower Lp(a) levels may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment strategies for cardiovascular disease in populations with high Lp(a) levels.
How similar studies have performed: Previous research has shown that genetic factors significantly influence Lp(a) levels, indicating that this approach has potential for success.
Where this research is happening
NEW YORK, UNITED STATES
- COLUMBIA UNIVERSITY HEALTH SCIENCES — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: REYES-SOFFER, GISSETTE — COLUMBIA UNIVERSITY HEALTH SCIENCES
- Study coordinator: REYES-SOFFER, GISSETTE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Atherosclerotic Cardiovascular Disease