Understanding how genetic factors contribute to juvenile arthritis
Epigenetic Mechanisms That Drive Genetic Risk in Juvenile Arthritis
This study is looking at how certain genes might make kids more likely to develop juvenile idiopathic arthritis, with the hope of finding better ways to treat the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11167039 on NIH RePORTER |
What this research studies
This research investigates the genetic mechanisms that increase the risk of juvenile idiopathic arthritis (JIA) in children. By focusing on specific genetic variants and their effects on gene expression, the study aims to identify the biological pathways that lead to this autoimmune condition. The research utilizes advanced techniques like ATAC sequencing to analyze how these genetic factors influence immune cells, particularly CD4+ T cells. This approach seeks to provide a deeper understanding of the disease, potentially leading to more targeted treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years who are at risk for or diagnosed with juvenile idiopathic arthritis.
Not a fit: Patients who are older than 11 years or do not have a genetic predisposition to juvenile arthritis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment strategies for children at risk of developing juvenile arthritis.
How similar studies have performed: Previous research has shown success in understanding genetic mechanisms in other autoimmune diseases, suggesting that this approach could yield valuable insights for juvenile arthritis as well.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Jarvis, James N — University of Washington
- Study coordinator: Jarvis, James N
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.