Understanding how genetic diversity evolves over time
Official title: Novel Coalescent Approaches for Studying Evolutionary Processes
Funded at Stanford University · NIH-11067859 · Data updated 2026-11-12
This study is looking at how genetic differences happen in people and whether they are caused by helpful changes or just random chance, which could help us understand genetic disorders better and how they relate to our evolution.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | May 17, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $386,000 |
| NIH project number | 5R35GM148338-03 |
| Project ID | NIH-11067859 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit include individuals with genetic disorders or those interested in the genetic basis of diseases.
✕Less likely to help
Patients with non-genetic conditions or those not affected by genetic diversity may not receive any benefit from this research.
What this research studies
This research investigates the evolutionary processes that shape genetic diversity by developing new statistical models and computational methods. It aims to determine whether observed genetic variations are due to adaptive changes or random factors, and to identify specific genomic regions that are under selection. By analyzing molecular data and genealogical patterns, the research seeks to provide insights into the forces influencing genetic variation across different populations and environments. Patients may benefit from a better understanding of genetic disorders and their evolutionary backgrounds.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of genetic disorders and lead to improved strategies for diagnosis and treatment.
How similar studies have gone: Other research has successfully utilized Bayesian approaches and coalescent models to study evolutionary processes, indicating a promising foundation for this work.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Palacios, Julia — Stanford University
- Study coordinator: Palacios, Julia
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.