Understanding how genetic differences affect vitamin D's role in Sjögren’s disease
Establishing the role of genetic variation in vitamin D-regulated gene expression in Sjogrens disease pathogenesis
This study is looking at how your genes and vitamin D might work together to affect Sjögren’s disease, which could help us find new ways to understand and treat this condition.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Berkeley NIH-funded |
| Lab location | 1 site (Berkeley, United States) |
| Project ID | NIH-10907767 on NIH RePORTER |
What this research studies
This research investigates the connection between genetic variations and the way vitamin D influences gene expression in Sjögren’s disease, an autoimmune condition affecting many individuals. By analyzing how vitamin D receptors interact with specific genetic markers, the study aims to uncover new insights into the disease's pathogenesis. The approach includes using Mendelian randomization to assess the impact of low vitamin D levels on the risk of developing Sjögren’s disease. This could lead to a better understanding of the disease and potential new treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Sjögren’s disease or those at risk due to genetic factors.
Not a fit: Patients without Sjögren’s disease or those not genetically predisposed to autoimmune conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment strategies for patients with Sjögren’s disease.
How similar studies have performed: Previous research has shown promising results in understanding the role of vitamin D in autoimmune diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Berkeley, United States
- University of California Berkeley — Berkeley, United States (Active)
Researchers
- Principal investigator: Yilmaz, Defne — University of California Berkeley
- Study coordinator: Yilmaz, Defne
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.