Understanding how genetic differences affect proteins in the body
Official title: Investigating the functional impact of genetic variants in the human proteome
Funded at Ohio State University · NIH-10917226 · Data updated 2026-11-12
This study is looking at how tiny differences in our genes can affect the proteins our bodies make, which might help us understand and treat diseases like amyloidosis and cancer better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | September 1, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $393,750 |
| NIH project number | 5R35GM150723-02 |
| Project ID | NIH-10917226 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with known genetic variants related to amyloidosis or other genetic disorders.
✕Less likely to help
Patients without any genetic disorders or those not affected by amyloidosis may not benefit from this research.
What this research studies
This research investigates how small genetic variations among individuals can influence the proteins produced in the body, which may have significant implications for health and disease. By analyzing both inherited and acquired genetic changes, the study aims to identify which variants are linked to specific diseases, particularly focusing on conditions like amyloidosis and cancer. The researchers will utilize advanced mass spectrometry techniques to measure these genetic variants and develop new bioinformatics tools to interpret the data. This approach could lead to better diagnostic and treatment strategies for patients with genetic disorders.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with genetic disorders and cancers.
How similar studies have gone: Previous research has shown promise in using proteomics to understand genetic variants, indicating that this approach could yield valuable insights.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Searle, Brian Chih-Seng — Ohio State University
- Study coordinator: Searle, Brian Chih-Seng
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.