Understanding how genetic differences affect health
Causes and consequences of regulatory genetic variation
['FUNDING_OTHER'] · UNIVERSITY OF MINNESOTA · NIH-11139426
This project explores how tiny changes in our DNA can lead to differences in gene activity, which might explain why some people develop common conditions like heart disease or autoimmune disorders.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MINNESOTA (nih funded) |
| Locations | 1 site (MINNEAPOLIS, UNITED STATES) |
| Trial ID | NIH-11139426 on ClinicalTrials.gov |
What this research studies
Our bodies are unique because of small differences in our DNA, and this project aims to understand how these genetic variations influence our health. We want to find out which specific DNA changes truly affect how our genes work, and how these changes might lead to conditions like heart disease or autoimmune problems. We are also looking into how genetic differences can specifically alter the amount of protein a gene makes, even if the gene's instructions (mRNA) stay the same. By combining computer analysis with laboratory experiments, we hope to better understand how these precise genetic differences shape our traits and health.
Who could benefit from this research
Good fit: This foundational work is not directly recruiting patients but aims to understand the genetic basis of diseases relevant to individuals with or at risk for cardiovascular, autoimmune, and neurological conditions.
Not a fit: Patients seeking immediate new treatments or direct clinical intervention would not find direct benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could help us better understand the root causes of common human diseases, potentially leading to new ways to predict risk or develop treatments.
How similar studies have performed: While the broad field of genetic variation is well-established, this project addresses fundamental, unanswered questions about the specific mechanisms and consequences of regulatory genetic variation.
Where this research is happening
MINNEAPOLIS, UNITED STATES
- UNIVERSITY OF MINNESOTA — MINNEAPOLIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ALBERT, FRANK WOLFGANG — UNIVERSITY OF MINNESOTA
- Study coordinator: ALBERT, FRANK WOLFGANG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autoimmune Diseases, Cardiovascular Diseases