Understanding how genetic changes in receptors affect autoimmune diseases
GPCR biology in autoimmunity: bridging genetics to structure to decipher mechanisms of disease
This study is looking at how certain genetic changes in receptors in our cells might affect autoimmune diseases, with the goal of finding better treatments that are personalized for patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11023197 on NIH RePORTER |
What this research studies
This research investigates the role of genetic variants in G-protein coupled receptors (GPCRs) and their impact on autoimmune diseases. By using advanced techniques in biophysics and structural biology, the team aims to understand how these genetic changes alter receptor structure and function. The findings will help develop new therapeutic strategies targeting these receptors to improve treatment for autoimmune conditions. Patients may benefit from insights that lead to more effective interventions tailored to their genetic profiles.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with autoimmune diseases who have specific genetic variants associated with GPCRs.
Not a fit: Patients without autoimmune conditions or those whose genetic profiles do not involve GPCR variants may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that specifically target the genetic mechanisms underlying autoimmune diseases.
How similar studies have performed: Previous research has shown promise in understanding GPCRs in relation to autoimmune diseases, indicating that this approach could yield valuable insights.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Xavier, Ramnik J — Massachusetts General Hospital
- Study coordinator: Xavier, Ramnik J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.