Understanding how genetic changes in receptors affect autoimmune diseases
Official title: GPCR biology in autoimmunity: bridging genetics to structure to decipher mechanisms of disease
Funded at Massachusetts General Hospital · NIH-11023197 · Data updated 2026-11-12
This study is looking at how certain genetic changes in receptors in our cells might affect autoimmune diseases, with the goal of finding better treatments that are personalized for patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | November 21, 2024 |
| Project end | October 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $800,005 |
| NIH project number | 1R01AI187288-01 |
| Project ID | NIH-11023197 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with autoimmune diseases who have specific genetic variants associated with GPCRs.
✕Less likely to help
Patients without autoimmune conditions or those whose genetic profiles do not involve GPCR variants may not benefit from this research.
What this research studies
This research investigates the role of genetic variants in G-protein coupled receptors (GPCRs) and their impact on autoimmune diseases. By using advanced techniques in biophysics and structural biology, the team aims to understand how these genetic changes alter receptor structure and function. The findings will help develop new therapeutic strategies targeting these receptors to improve treatment for autoimmune conditions. Patients may benefit from insights that lead to more effective interventions tailored to their genetic profiles.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that specifically target the genetic mechanisms underlying autoimmune diseases.
How similar studies have gone: Previous research has shown promise in understanding GPCRs in relation to autoimmune diseases, indicating that this approach could yield valuable insights.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Xavier, Ramnik J — Massachusetts General Hospital
- Study coordinator: Xavier, Ramnik J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.