Understanding how genetic changes affect gene activity across the genome
Official title: The transcriptome-wide impact of biological perturbations
Funded at Harvard Medical School · NIH-10815539 · Data updated 2026-11-12
This study is looking at how differences in our genes affect how other genes work, especially in people with chronic myeloid leukemia, to help find better ways to treat the disease.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard Medical School NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | May 1, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $36,856 |
| NIH project number | 5F31HG013036-02 |
| Project ID | NIH-10815539 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with chronic myeloid leukemia or those interested in the genetic basis of cancer.
✕Less likely to help
Patients with conditions unrelated to genetic variations affecting gene expression may not receive direct benefits from this research.
What this research studies
This research investigates the broad effects of genetic variations on gene expression using advanced computational methods. By developing a new statistical tool called the Transcriptome-wide Impact Model (TIM), the study aims to capture the widespread impact of certain genes, particularly those that regulate chromatin, on thousands of other genes. The approach involves analyzing RNA sequencing data to identify how these genetic perturbations influence cellular processes in both healthy and disease contexts, specifically focusing on chronic myeloid leukemia. Patients may benefit from insights gained about gene interactions and their implications for cancer treatment.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of cancer biology and more effective treatment strategies for patients with genetic disorders.
How similar studies have gone: Previous research has shown promise in using similar high-throughput methods to understand gene expression changes, indicating that this approach could yield valuable insights.
Where this research is happening
-
Harvard Medical School
Boston, United States Active
Researchers
- Principal investigator: Nadig, Ajay — Harvard Medical School
- Study coordinator: Nadig, Ajay
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.