Understanding how genetic and epigenetic factors influence cocaine addiction
The Genetic and Epigenetic Interplay of Cocaine Addiction: A Cell-Type, Circuitry, and Functional Dissection
This study is looking at how genes and their changes affect cocaine addiction in mice, hoping to learn more about what makes some people more likely to struggle with cocaine use.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-10935638 on NIH RePORTER |
What this research studies
This research investigates the complex interplay between genetic and epigenetic factors that contribute to cocaine addiction using a mouse model. By analyzing the changes in gene expression and epigenetic modifications after cocaine self-administration, the study aims to identify specific cellular and circuit-level alterations. The project employs advanced techniques such as DNA methylation profiling and chromatin accessibility assessments to uncover the biological mechanisms behind addiction. Ultimately, this research seeks to enhance our understanding of how these factors influence behavior and susceptibility to cocaine use disorder.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of cocaine use disorder or those at risk of developing such conditions.
Not a fit: Patients who do not have a history of substance use disorders or are not affected by cocaine addiction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the biological mechanisms of cocaine addiction, potentially informing future treatment strategies.
How similar studies have performed: Previous research has shown promising results in understanding addiction through genetic and epigenetic studies, indicating that this approach has potential for significant findings.
Where this research is happening
Chicago, United States
- University of Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Zhang, Zhuzhu — University of Chicago
- Study coordinator: Zhang, Zhuzhu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.